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The researchers found new molecular pathways of resistance, including hypoxia tolerance, protein folding, and mitochondria respiration.
Using single-cell and bulk RNA sequence data, investigators identified four pathway-based GBM subtypes, including a mitochondrial subtype that appears to respond to related inhibitors.
Tumor microenvironment cell transcriptomes pointed to four stromal cell clusters, including immune interacting support cells predicted to impact immunotherapy response.
SkylineDx said that the firms will work together to develop predictive immunological signatures for BioInvent's lead therapy candidate.
Researchers have identified immune cell gene expression signatures that could one day be developed into tests to predict response to treatment.