Advances in Spatial Genomics

Multiple Myeloma Therapy Targets, Resistance Pathways Identified With Single-Cell Sequencing

The researchers found new molecular pathways of resistance, including hypoxia tolerance, protein folding, and mitochondria respiration.

Glioblastoma Transcriptomes Point to Mitochondrial Subtype, Potential Treatment Strategies

Using single-cell and bulk RNA sequence data, investigators identified four pathway-based GBM subtypes, including a mitochondrial subtype that appears to respond to related inhibitors.

Triple-Negative Breast Cancer Treatment Hints Drawn From Single-Cell Study

Tumor microenvironment cell transcriptomes pointed to four stromal cell clusters, including immune interacting support cells predicted to impact immunotherapy response.

SkylineDx, BioInvent Collaborate to Characterize Predictive Immunological Signatures for Cancers

SkylineDx said that the firms will work together to develop predictive immunological signatures for BioInvent's lead therapy candidate.

B Cell Gene Expression Profiling May Enable Cancer Immunotherapy CDx Test

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Researchers have identified immune cell gene expression signatures that could one day be developed into tests to predict response to treatment.