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The firm will conduct genomic and transcriptomic analysis to identify predictors of response to the personalized immunotherapy TG4050.
The company said data from the Phase II portion of the CodeBreak-100 study in KRAS-mutated lung cancer patients was positive and may be registrational.
The Phase I/II trial will assess the safety and efficacy of the CAR T cell therapy MB-102 for patients with three types of hematologic malignancies.
The Phase I trial evaluated the safety and maximum tolerated dose of BAY-1895344 along with objective response rate among patients with DDR deficiencies.
The Swiss company will assess the agent both alone and combined with Tecentriq as a treatment for FGFR-positive gastric cancer.
The research showed that atezolizumab plus nab-paclitaxel provided survival benefits, as did an antibody-drug conjugate that was recently approved by the FDA.
The trial, which received positive feedback from the FDA, will enroll patients who have a biomarker that may increase their chances of responding to the drug.
The company is developing T-cell receptor therapies, several of which have entered early-phase trials, that target unique peptides identified through mass spectrometry.
The trial will assess the safety and tolerability of Zion's ZN-A-1041 in patients with HER2-positive tumors, including those with brain metastases.