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NEW YORK – Agios Pharmaceuticals said on Monday that its Phase III ClarIDHy trial did not demonstrate a statistically significant survival advantage for ivosidenib (Tibsovo) in patients with IDH1-mutated cholangiocarcinoma compared to placebo.

The ClarIDHy has already met its primary endpoint by demonstrating that patients with IDH1-mutated tumors on ivosidenib had a median progression-free survival of 2.7 months compared to 1.4 months on placebo. 

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