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NEW YORK – Aileron Therapeutics said on Monday that it has enrolled the first patient in its Phase IB/II trial evaluating whether pretreating TP53-mutated small-cell lung cancer patients with its investigational drug ALRN-6924 can reduce the chemotherapy-induced toxicities associated with topotecan.

Prior to enrollment, patients must have either recurred or relapsed on chemotherapy or immunochemotherapy and have their TP53 mutation status confirmed by next-generation sequencing.

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