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NEW YORK – Cardiff Oncology said on Tuesday it will begin a Phase II trial of its PLK1 inhibitor onvansertib in patients with metastatic pancreatic ductal adenocarcinoma.

The single-arm trial will evaluate onvansertib in combination with nanoliposomal irinotecan (Ipsen Biopharmaceuticals' Onyvide) and chemotherapy as a second-line treatment for the pancreatic cancer subtype. Cardiff Oncology was cleared to begin the study by the US Food and Drug Administration after it accepted the company's investigational new drug application.

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