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NEW YORK – Celyad Oncology said on Tuesday that it is partnering with Merck to conduct a study in which its investigational CAR T-cell therapy, CYAD-101, will be evaluated in combination with Merck's anti-PD-1 therapy pembrolizumab (Keytruda) in certain advanced colorectal cancer patients.

In the Phase Ib Keynoted-B79 trial, refractory and metastatic colorectal cancer patients will receive FOLFIRI as preconditioning chemotherapy before receiving CYAD-101 and pembrolizumab, and their tumors must be microsatellite stable or mismatch repair proficient.

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Sponsored by
LGC SeraCare Life Sciences

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