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NEW YORK – Daiichi Sankyo on Thursday announced it had entered into a collaboration with AstraZeneca to evaluate the combination of its experimental HER3-directed DXd antibody drug conjugate, patritumab deruxtecan (U3-1402) in combination with AstraZeneca's TKI osimertinib (Tagrisso) in a two-part Phase I clinical trial for the treatment of patients with advanced or metastatic EGFR-mutated non-small cell lung cancer (NSCLC).

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NTRK fusions are oncogenic drivers in a variety of tumors.

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This webinar, Part 3 of the “Advances in RNA-based Biomarker Development for Precision Oncology” webinar series sponsored by GeneCentric Therapeutics, will discuss novel and emerging applications of RNA-based genomic analysis in precision oncology, form characterizing the tumor microenvironment to informing the development of immuno-oncology treatments.

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Circulating tumor DNA (ctDNA) can allow clinicians and researchers to better understand which patients are at high risk of recurrence and should be offered intensified chemotherapy or selected for clinical trials.


In non-small cell lung cancer (NSCLC), early detection of emerging resistance mutations such as EGFR T790M is important in order to determine the appropriate targeted therapeutic strategy.