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NEW YORK (GenomeWeb) – A group led by researchers at the Icahn School of Medicine at Mount Sinai has built a fruit fly model to develop a personalized therapy for a patient with treatment-resistant metastatic KRAS-mutation colorectal cancer (CRC).

Specifically, the team altered orthologs of nine key driver genes identified through genomic analysis of a patient's tumor and conducted a robotic screen of the fruit fly models to find that a combination of trametinib and zoledronate could act as a cancer treatment option.

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