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NEW YORK (GenomeWeb) – Metastatic breast cancer tumors that express the estrogen receptor often acquire HER2 mutations that make them resistant to treatments targeting the estrogen receptor.

About 80 percent of breast cancers are ER+, according to the National Institutes of Health. According to a team led by researchers at the Dana-Farber Cancer Institute, nearly all patients with ER+breast cancers that become metastatic develop resistance to treatments that target the estrogen receptor.

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