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NEW YORK – Investigators from the Targeted Agent and Profiling Utilization Registry (TAPUR) study have shown that palbociclib (Pfizer's Ibrance) shows activity in some non-small cell lung cancer patients with alterations in CDKN2A.
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The Phosphoinositide 3-Kinase (PI3K) pathway is one of the most frequently altered pathways in human cancer and plays a significant role in disease progression and resistance to endocrine therapy.