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NEW YORK – Advanced lung cancer patients with ALK rearrangements may soon have another ALK inhibitor to choose from as a front-line option according to interim Phase III study data presented at the European Society for Medical Oncology's Virtual Congress on Saturday.

Data from a planned interim analysis in the CROWN trial comparing Pfizer's third-generation ALK inhibitor lorlatinib (Lorbrena) against its first-generation drug crizotinib (Xalkori) showed that the newer agent shrunk tumors in 76 percent of patients compared to a 58 percent overall response rate with the older drug.

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Dec
02
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Qiagen

The Phosphoinositide 3-Kinase (PI3K) pathway is one of the most frequently altered pathways in human cancer and plays a significant role in disease progression and resistance to endocrine therapy.