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NEW YORK – Mutations in the estrogen receptor alpha-coding gene ESR1 appear to occur in a small subset of primary breast cancer tumors, potentially providing a window into cases with poorer-than-usual responses to adjuvant, endocrine-based treatments.

Several prior studies suggest activating mutations in ESR1 can contribute to treatment resistance in metastatic breast cancer cases, explained Malin Dahlgren, a doctoral student in Lao Saal's oncology and pathology lab at Lund University.

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Feb
11
Sponsored by
Foundation Medicine

In this session, the first in the Precision Oncology News Virtual Molecular Tumor Board Series, our expert panelists will review patient cases in which genomic profiling has identified biomarkers related to homologous recombination deficiency and DNA damage repair.

Feb
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Sponsored by
Qiagen

Please join GenomeWeb and Qiagen for an online roundtable discussion where a panel of experts will review challenges and opportunities around genomic variant interpretation workflows in the field of oncology.

Feb
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Sponsored by
Foundation Medicine

In this session, the second in the Precision Oncology News Virtual Molecular Tumor Board Series, our expert panelists will review cases in which patient genomic profiles exhibit common driver mutations in tumor types considered “off label” for targeted therapies associated with those mutations.

Mar
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Sponsored by
Foundation Medicine

In this session, the third in the Precision Oncology News Virtual Molecular Tumor Board Series, our expert panelists will review patient cases in which genomic profiling has identified gene fusions that may or may not serve as druggable targets.