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NEW YORK – Immuno-methylomic profiling of the tumor immune microenvironment of pediatric central nervous system tumors may offer prognostic data and help guide therapeutic decisions, according to a new study.

Tumors are often broken into two immunological groups, those that are "hot" and have tumor immune microenvironments that harbor immune cells and those that are "cold" and are sparsely populated by immune cells. In general, pediatric brain tumors are thought to be "cold" as they have few mutations and neoantigens.

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