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NEW YORK – Tempest Therapeutics announced Thursday that the investigational new drug application for TPST-1495 has been accepted by the US Food and Drug Administration. The company will now initiate a Phase Ia/Ib clinical trial in solid tumors, with a focus on patients with microsatellite stable colorectal cancer.

TPST-1495 is a first-in-human investigational agent that inhibits prostaglandin receptors EP2 and EP4, which have been strongly implicated in colorectal cancer

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