Genomics: Clinical Implementation

This channel includes news headlines and educational resources regarding the clinical implementation of genomics assays, including development, validation, quality control, standardization, and the practical and commercial considerations for labs adopting these tests.

AMP Attendees Reflect on Uptake of Tumor Mutational Burden Amid Validation, Utility Questions

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In a survey conducted by an association working group, 40 percent of respondents said they are already offering TMB, with most others planning to do the same within the year.

NSGC Panel Divided on Whether Newly Diagnosed Breast Cancer Patients Should Undergo Panel Testing

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Genetic testing results increasingly inform clinical decisions, though the inclusion of hereditary risk genes beyond BRCA1, BRCA2, and PALB2 sparked debate.

CIViC Developers Enhancing Variant Database for Greater Use in Precision Oncology

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With a $3.7 million NIH grant, database developers hope to garner FDA recognition, develop a new user interface, and further integrate its use in cancer care.

CMS Proposes New National Coverage Policy for NGS Germline Testing

CMS has attempted to address stakeholders' concerns about its coverage criteria for germline NGS testing in a new proposed national policy.

Genomic Test Makers Pilot New Approaches to Overcome Roadblocks in CUP Patient Treatment

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Negative results in recent trials have highlighted the challenges that newer genomic test makers must overcome in proving methods for personalized CUP treatment.

Oct 23, 2019

Metastatic Tumor Profiles Lead to Potential Treatment Targets

Oct 18, 2019

Colon Cancer Recurrence Clues Identified in Post-Treatment ctDNA Detection

Sep 30, 2019

Netherlands Drug Repurposing, Tumor Profiling Trial Results Reported at ESMO

Sep 10, 2019

European Labs Continue to Validate, Implement TMB, Facing Down Cutoff Discordance Concerns

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Sep 05, 2019

Large-Scale Multigene Panel Study of Hereditary Cancer Risk Refines Gene Associations

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Aug 29, 2019

Veterans Health Administration Precision Oncology Program Successfully Profiles Advanced Tumors

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Aug 26, 2019

Stakeholders Voice Concerns, Push Back on NCD for NGS Cancer Panels

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Aug 20, 2019

USPSTF Formalizes Slightly Expanded BRCA Screening Recommendations

Aug 13, 2019

Complex Genetic Testing Errors Emerge Amid Increasing Panel Use, Consumer Access, Case Series Finds

Aug 07, 2019

Pediatric Cancer Researchers, Clinicians Look to Enhance Molecular Data Collection, Distribution

Aug 02, 2019

Comparison of KRAS Liquid Biopsy Kits Confirms Differences at Low Mutant Allele Fraction

Jul 26, 2019

CancerLinQ Calls on MDx Labs to Share Structured Genomic Reports to Support Precision Oncology

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Jul 25, 2019

Lynch Syndrome Mutation Study Suggests Changes to Clinical Management

Jul 10, 2019

Multi-Gene Panel Testing Moderately Cost Effective for Lung Cancer Patients

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Jun 21, 2019

Liquid Biopsy Monitoring, Surveillance Efforts Accelerate Across Cancer Types and Technologies

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Jun 18, 2019

Next-Generation Sequencing of Pediatric Cancer Patients Could Transform Treatment Paradigms

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Jun 17, 2019

Wake Forest Researchers Learn From Patient Data in Offering Precision Oncology Broadly

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Jun 11, 2019

Multi-Gene Panel Testing Finds Pathogenic Variant Carriers Missed Under Current Testing Guidelines

May 16, 2019

NCI Pediatric MATCH Trial Interim Data Shows 24 Percent of Patients Eligible for Targeted Therapy

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May 09, 2019

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Genomics: Clinical Implementation

AMP Attendees Reflect on Uptake of Tumor Mutational Burden Amid Validation, Utility Questions

NSGC Panel Divided on Whether Newly Diagnosed Breast Cancer Patients Should Undergo Panel Testing

CIViC Developers Enhancing Variant Database for Greater Use in Precision Oncology

CMS Proposes New National Coverage Policy for NGS Germline Testing

Genomic Test Makers Pilot New Approaches to Overcome Roadblocks in CUP Patient Treatment

Metastatic Tumor Profiles Lead to Potential Treatment Targets

Colon Cancer Recurrence Clues Identified in Post-Treatment ctDNA Detection

Netherlands Drug Repurposing, Tumor Profiling Trial Results Reported at ESMO

European Labs Continue to Validate, Implement TMB, Facing Down Cutoff Discordance Concerns

Large-Scale Multigene Panel Study of Hereditary Cancer Risk Refines Gene Associations

Veterans Health Administration Precision Oncology Program Successfully Profiles Advanced Tumors

Stakeholders Voice Concerns, Push Back on NCD for NGS Cancer Panels

USPSTF Formalizes Slightly Expanded BRCA Screening Recommendations

Complex Genetic Testing Errors Emerge Amid Increasing Panel Use, Consumer Access, Case Series Finds

Pediatric Cancer Researchers, Clinicians Look to Enhance Molecular Data Collection, Distribution

Comparison of KRAS Liquid Biopsy Kits Confirms Differences at Low Mutant Allele Fraction

CancerLinQ Calls on MDx Labs to Share Structured Genomic Reports to Support Precision Oncology

Lynch Syndrome Mutation Study Suggests Changes to Clinical Management

Multi-Gene Panel Testing Moderately Cost Effective for Lung Cancer Patients

Liquid Biopsy Monitoring, Surveillance Efforts Accelerate Across Cancer Types and Technologies

Next-Generation Sequencing of Pediatric Cancer Patients Could Transform Treatment Paradigms

Wake Forest Researchers Learn From Patient Data in Offering Precision Oncology Broadly

Multi-Gene Panel Testing Finds Pathogenic Variant Carriers Missed Under Current Testing Guidelines

NCI Pediatric MATCH Trial Interim Data Shows 24 Percent of Patients Eligible for Targeted Therapy

Circulating Tumor DNA Forecasts Recurrence in Non-Metastatic Colorectal Cancer

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