Genomics: Clinical Implementation

This channel includes news headlines and educational resources regarding the clinical implementation of genomics assays, including development, validation, quality control, standardization, and the practical and commercial considerations for labs adopting these tests.

Multi-Gene Panel Testing Moderately Cost Effective for Lung Cancer Patients

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A Personalized Medicine Coalition-funded study has found that NGS-based testing is moderately cost effective but that access to targeted treatments remains a hurdle.

Liquid Biopsy Monitoring, Surveillance Efforts Accelerate Across Cancer Types and Technologies

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Presentations at this month's ASCO meeting demonstrated how efforts are advancing to determine when and how longitudinal ctDNA testing will be useful for oncologists.

Next-Generation Sequencing of Pediatric Cancer Patients Could Transform Treatment Paradigms

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Combined DNA/RNA-seq efforts in various settings could lead to new ways of treating kids with drugs meant for adults or to the development of new therapies.

Wake Forest Researchers Learn From Patient Data in Offering Precision Oncology Broadly

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The researchers found differences in mutational patterns among their African-American patients and that liquid biopsies seem to catch metastases early.

Multi-Gene Panel Testing Finds Pathogenic Variant Carriers Missed Under Current Testing Guidelines

Color researchers reported that 21.7 percent of individuals with pathogenic variants in well-established genes did not meet guidelines for testing.

May 16, 2019

NCI Pediatric MATCH Trial Interim Data Shows 24 Percent of Patients Eligible for Targeted Therapy

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May 09, 2019

Circulating Tumor DNA Forecasts Recurrence in Non-Metastatic Colorectal Cancer

May 02, 2019

Immunotherapy Response in MMR-Deficient Tumors Linked to MSI Levels, Indel Mutations

May 01, 2019

CMS Reopens National Coverage Determination for NGS Testing in Advanced Cancer

Apr 26, 2019

Inivata Clinical Validation Bolsters Liquid Biopsy Evidence Base, Aids Platform Comparisons

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Apr 22, 2019

Molecular Profiling of Cancer Patients Uncovers Combination Treatments in I-PREDICT Study

Apr 22, 2019

WINTHER Trial Highlights Challenges, Potential of Transcriptomics for Precision Oncology

Apr 22, 2019

Liquid Biopsy Utility Reinforced in Early Results From UK TARGET Program

Apr 10, 2019

Foundation Medicine, Flatiron Health Publish Clinical Validity of Clinico-Genomics Database

Apr 09, 2019

Immunotherapy Developers, Clinical Researchers Continue to Seek New Dx Strategies

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Apr 08, 2019

Cancer Sequencing Finds Germline Risk Variants in Many CHOP Pediatric Cancer Cases

Apr 08, 2019

Expanded Germline Panel Testing in Cancer Patients Catches Risk Variants Missed by Focused Tests

Apr 05, 2019

Color, NorthShore Pilot Project Results Reported at ACMG

Apr 04, 2019

Memorial Sloan Kettering Nears Approval for Liquid Biopsy Test; Describes Validation at AACR

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Apr 03, 2019

Resolution Bio Liquid Biopsy Outperforms Guardant Test in Lung Cancer Gene Fusion Detection

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Apr 02, 2019

AACR Liquid Biopsy Studies Demonstrate Diversity of Methods for Early Cancer Detection

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Apr 01, 2019

Bayer, Loxo Next-Generation TRK Inhibitor Shows Promising Activity in AACR Study

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Apr 01, 2019

Guardant Health AACR Data Hint at Future Potential of Bellwether Acquisition

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Mar 29, 2019

AstraZeneca Liquid Biopsy Comparison Details Concordance Failures

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Mar 27, 2019

Nationwide Children's Aims to Demonstrate Benefits of Comprehensive Cancer Sequencing

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Genomics: Clinical Implementation

Multi-Gene Panel Testing Moderately Cost Effective for Lung Cancer Patients

Liquid Biopsy Monitoring, Surveillance Efforts Accelerate Across Cancer Types and Technologies

Next-Generation Sequencing of Pediatric Cancer Patients Could Transform Treatment Paradigms

Wake Forest Researchers Learn From Patient Data in Offering Precision Oncology Broadly

Multi-Gene Panel Testing Finds Pathogenic Variant Carriers Missed Under Current Testing Guidelines

NCI Pediatric MATCH Trial Interim Data Shows 24 Percent of Patients Eligible for Targeted Therapy

Circulating Tumor DNA Forecasts Recurrence in Non-Metastatic Colorectal Cancer

Immunotherapy Response in MMR-Deficient Tumors Linked to MSI Levels, Indel Mutations

CMS Reopens National Coverage Determination for NGS Testing in Advanced Cancer

Inivata Clinical Validation Bolsters Liquid Biopsy Evidence Base, Aids Platform Comparisons

Molecular Profiling of Cancer Patients Uncovers Combination Treatments in I-PREDICT Study

WINTHER Trial Highlights Challenges, Potential of Transcriptomics for Precision Oncology

Liquid Biopsy Utility Reinforced in Early Results From UK TARGET Program

Foundation Medicine, Flatiron Health Publish Clinical Validity of Clinico-Genomics Database

Immunotherapy Developers, Clinical Researchers Continue to Seek New Dx Strategies

Cancer Sequencing Finds Germline Risk Variants in Many CHOP Pediatric Cancer Cases

Expanded Germline Panel Testing in Cancer Patients Catches Risk Variants Missed by Focused Tests

Color, NorthShore Pilot Project Results Reported at ACMG

Memorial Sloan Kettering Nears Approval for Liquid Biopsy Test; Describes Validation at AACR

Resolution Bio Liquid Biopsy Outperforms Guardant Test in Lung Cancer Gene Fusion Detection

AACR Liquid Biopsy Studies Demonstrate Diversity of Methods for Early Cancer Detection

Bayer, Loxo Next-Generation TRK Inhibitor Shows Promising Activity in AACR Study

Guardant Health AACR Data Hint at Future Potential of Bellwether Acquisition

AstraZeneca Liquid Biopsy Comparison Details Concordance Failures

Nationwide Children's Aims to Demonstrate Benefits of Comprehensive Cancer Sequencing

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