Genomics: Clinical Implementation

This channel includes news headlines and educational resources regarding the clinical implementation of genomics assays, including development, validation, quality control, standardization, and the practical and commercial considerations for labs adopting these tests.

European Labs Continue to Validate, Implement TMB, Facing Down Cutoff Discordance Concerns

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As labs implement TMB workflows in-house, studies are showing that its is possible to validate assays with cutoff points remaining stable across complex clinical cohorts and in different drug contexts.

Large-Scale Multigene Panel Study of Hereditary Cancer Risk Refines Gene Associations

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The team analyzed multigene panel test data from Ambry Genetics for 165,000 individuals, focusing on hereditary cancer risk related to 32 genes in six cancer types.

Veterans Health Administration Precision Oncology Program Successfully Profiles Advanced Tumors

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Since 2016, the VHA has routinely profiled molecular features in advanced cancers from vets in its care, even in rural locales, though challenges remain.

Stakeholders Voice Concerns, Push Back on NCD for NGS Cancer Panels

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In response to CMS reopening its national coverage determination to address its germline testing policy, stakeholders point out areas of concern and confusion.

USPSTF Formalizes Slightly Expanded BRCA Screening Recommendations

After reviewing more than 100 studies, the panel issued recommendations focused on women with a personal or family history of BRCA1/2-related cancers or high-risk ancestry.

Aug 13, 2019

Complex Genetic Testing Errors Emerge Amid Increasing Panel Use, Consumer Access, Case Series Finds

Aug 07, 2019

Pediatric Cancer Researchers, Clinicians Look to Enhance Molecular Data Collection, Distribution

Aug 02, 2019

Comparison of KRAS Liquid Biopsy Kits Confirms Differences at Low Mutant Allele Fraction

Jul 26, 2019

CancerLinQ Calls on MDx Labs to Share Structured Genomic Reports to Support Precision Oncology

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Jul 25, 2019

Lynch Syndrome Mutation Study Suggests Changes to Clinical Management

Jul 10, 2019

Multi-Gene Panel Testing Moderately Cost Effective for Lung Cancer Patients

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Jun 21, 2019

Liquid Biopsy Monitoring, Surveillance Efforts Accelerate Across Cancer Types and Technologies

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Jun 18, 2019

Next-Generation Sequencing of Pediatric Cancer Patients Could Transform Treatment Paradigms

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Jun 17, 2019

Wake Forest Researchers Learn From Patient Data in Offering Precision Oncology Broadly

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Jun 11, 2019

Multi-Gene Panel Testing Finds Pathogenic Variant Carriers Missed Under Current Testing Guidelines

May 16, 2019

NCI Pediatric MATCH Trial Interim Data Shows 24 Percent of Patients Eligible for Targeted Therapy

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May 09, 2019

Circulating Tumor DNA Forecasts Recurrence in Non-Metastatic Colorectal Cancer

May 02, 2019

Immunotherapy Response in MMR-Deficient Tumors Linked to MSI Levels, Indel Mutations

May 01, 2019

CMS Reopens National Coverage Determination for NGS Testing in Advanced Cancer

Apr 26, 2019

Inivata Clinical Validation Bolsters Liquid Biopsy Evidence Base, Aids Platform Comparisons

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Apr 22, 2019

Molecular Profiling of Cancer Patients Uncovers Combination Treatments in I-PREDICT Study

Apr 22, 2019

WINTHER Trial Highlights Challenges, Potential of Transcriptomics for Precision Oncology

Apr 22, 2019

Liquid Biopsy Utility Reinforced in Early Results From UK TARGET Program

Apr 10, 2019

Foundation Medicine, Flatiron Health Publish Clinical Validity of Clinico-Genomics Database

Apr 09, 2019

Immunotherapy Developers, Clinical Researchers Continue to Seek New Dx Strategies

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Genomics: Clinical Implementation

European Labs Continue to Validate, Implement TMB, Facing Down Cutoff Discordance Concerns

Large-Scale Multigene Panel Study of Hereditary Cancer Risk Refines Gene Associations

Veterans Health Administration Precision Oncology Program Successfully Profiles Advanced Tumors

Stakeholders Voice Concerns, Push Back on NCD for NGS Cancer Panels

USPSTF Formalizes Slightly Expanded BRCA Screening Recommendations

Complex Genetic Testing Errors Emerge Amid Increasing Panel Use, Consumer Access, Case Series Finds

Pediatric Cancer Researchers, Clinicians Look to Enhance Molecular Data Collection, Distribution

Comparison of KRAS Liquid Biopsy Kits Confirms Differences at Low Mutant Allele Fraction

CancerLinQ Calls on MDx Labs to Share Structured Genomic Reports to Support Precision Oncology

Lynch Syndrome Mutation Study Suggests Changes to Clinical Management

Multi-Gene Panel Testing Moderately Cost Effective for Lung Cancer Patients

Liquid Biopsy Monitoring, Surveillance Efforts Accelerate Across Cancer Types and Technologies

Next-Generation Sequencing of Pediatric Cancer Patients Could Transform Treatment Paradigms

Wake Forest Researchers Learn From Patient Data in Offering Precision Oncology Broadly

Multi-Gene Panel Testing Finds Pathogenic Variant Carriers Missed Under Current Testing Guidelines

NCI Pediatric MATCH Trial Interim Data Shows 24 Percent of Patients Eligible for Targeted Therapy

Circulating Tumor DNA Forecasts Recurrence in Non-Metastatic Colorectal Cancer

Immunotherapy Response in MMR-Deficient Tumors Linked to MSI Levels, Indel Mutations

CMS Reopens National Coverage Determination for NGS Testing in Advanced Cancer

Inivata Clinical Validation Bolsters Liquid Biopsy Evidence Base, Aids Platform Comparisons

Molecular Profiling of Cancer Patients Uncovers Combination Treatments in I-PREDICT Study

WINTHER Trial Highlights Challenges, Potential of Transcriptomics for Precision Oncology

Liquid Biopsy Utility Reinforced in Early Results From UK TARGET Program

Foundation Medicine, Flatiron Health Publish Clinical Validity of Clinico-Genomics Database

Immunotherapy Developers, Clinical Researchers Continue to Seek New Dx Strategies

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