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The company will discuss with the FDA the possibility of using these preliminary Phase I results as part of its registrational package for the agent.
Developers are improving and expanding the software that has been helping match patients to molecularly targeted drugs at the institute for over three years.
Initial data on the PARIS test, combining functional drug testing and DNA sequencing, showed concordance between its predictions and patients' treatment responses.
In one study, the UK-based firm found that its RaDaR assay detected circulating tumor DNA in lung cancer patients up to a year before standard clinical progression occurred in most of the cases.
In a Phase Ia/Ib study, the anti-TIGIT antibody and Tecentriq combination had better anti-tumor activity than tiragolumab alone, particularly in PD-L1 expressing lung cancers.
Researchers reported a correlation between ctDNA clearance and progression-free survival in EGFR-positive, MET-amplified patients treated with Tagrisso and savolitinib.
Comprehensive analysis by a team led by Elaine Mardis has given 93 percent of around 150 pediatric cancer patients at least one medically actionable finding.
Investigators saw responses in one colorectal cancer and one breast cancer patient and are now studying differences between responders and non-responders.
The findings underscore the utility of universal germline testing in young adults diagnosed with cancers that are more common in older populations.
At AACR's annual meeting, a researcher described how the breakthrough therapy designated drug was designed specifically to overcome the challenges of targeting EGFR exon 20 insertions.