UCLA
Spectrum Solutions, UCLA Partner to Study Saliva-Based Early-Stage Lung Cancer Detection
The researchers will compare saliva and plasma samples from 50 patients with non-small cell lung cancer to identify circulating tumor DNA in saliva.
Somatic Mutations in Lung Cancer Patients With HLA Supertype B44 Influence Immunotherapy Response
The B44 supertype is associated with improved survival in melanoma patients treated with immunotherapy, but less so in NSCLC patients, due to mutational differences.
BFOR Study Uses Digital Tools to Facilitate Population BRCA Screening in Ashkenazi Jewish Community
Results show population screening can pick up risky BRCA1/2 mutations in men and women from Ashkenazi Jewish populations in the US, though engagement challenges remain.
PAK4 Inhibition Increases Anti-PD-1 Response in Mouse Models Prompting Phase I Trial
Researchers tested the combined treatment in mice, after detecting increased PAK4 expression and reduced immune infiltration in melanoma patients with poor anti-PD-1 response.
Advanced Breast Cancer Patients Benefit From Combination Therapy Including CDK4/6 Inhibitors
Two studies showed that the addition of abemaciclib or ribociclib to fulvestrant improved overall survival in HR-positive, HER2-negative breast cancer patients.