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With clinical sequencing data for almost 400 appendiceal cancer cases, researchers identified somatic differences in individuals diagnosed with the disease before the age of 50.
Research reported at the AACR annual meeting suggests mutations in the estrogen receptor gene ESR1 in untreated primary breast cancers can influence endocrine treatment response.
A new study supports the development of BET inhibitors for MYCN-driven triple negative breast cancer as a single agent and in combination with a MEK inhibitor.
While higher recurrence scores have been associated with increased mortality in women, the pattern of the association differed among male patients.
Researchers found that 14 percent of individuals with metastatic breast cancer had risky mutations germline mutations, including patients who did not meet testing criteria.
Cancer Moonshot-funded teams are profiling pre-cancers in an effort to establish targeted treatment, detection, and prevention methods that can be applied before cancers form.