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Precision Oncology Resources: Webinars

Tue
Jun
14
1:00 PM
US Eastern

Sponsored by Tempus

Transforming Drug Development with Real-World Data: Perspectives from Janssen’s Najat Khan

R&D leaders are increasingly investing in real-world data (RWD) solutions to accelerate and de-risk drug discovery, development, and commercialization. RWD is helping enable researchers to better understand diseases, identify unmet medical needs, and uncover new biomarkers that could lead to the development of more targeted medicines — all with the potential to drive better outcomes for patients. This is transforming the way R&D is done across all therapeutic areas, including in oncology, where the need for new, targeted therapies is particularly acute.

In this webinar, Najat Khan, Ph.D., chief data science officer and global head of strategy and operations for R&D at Janssen, will discuss how Janssen is applying advanced AI algorithms to RWD to achieve major development milestones in oncology R&D, from discovering biomarkers to matching patients with targeted therapies and clinical trials.

Participants will learn:

  • The value of matched clinical and molecular RWD throughout the therapy development process.
  • How AI-driven algorithmic biomarkers are being used to inform and optimize clinical trial design and identify potentially eligible patients.
  • How RWD and AI algorithms are informing Janssen’s approaches to R&D.

Sponsored by

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Thu
Jun
16
11:00 AM
US Eastern

Sponsored by Mission Bio

Bringing a New Standard of Clarity to Solid Tumor Research With Single-Cell Genomics

A major challenge to combating cancer is the dynamism and inherent heterogeneity contributing to the disease's onset, progression, and relapse. In the enormous efforts to identify the factors underlying these factors, bulk sequencing is widely used, but the need for unmasking the underlying genetic diversity across cell populations remains unmet.

Single-cell DNA sequencing can be used to interrogate clonal mosaicism and neoplastic transformation, metastatic dissemination, and therapeutic resistance with its ability to co-analyze SNVs and CNVs at the single-cell level in a scalable manner. As a tool for probing clonal architecture and evolution, researchers can identify zygosity, mutational co-occurrence, and rare mutations in individual cells.

Jorge Reis-Filho of Memorial Sloan Kettering Cancer Center will share the strategies for characterizing intratumor heterogeneity and evolutionary trajectories in cancers at the single-cell level and present his latest findings in breast cancer research.

This webinar will also present the latest advances in single-cell DNA sequencing, including pre-designed solid tumor DNA panels, single-cell CNV analysis workflow, and nuclei isolation protocols enabling solid tumor researchers to access this technology.

Attendees will:

  • Learn how single-cell DNA sequencing can bring a new level of clarity to research in solid tumors, such as breast cancer, by providing insights into the clonal architecture, mutation co-occurrence, and rare mutations driving tumor progression and therapy resistance.
  • Discover the science behind the Tapestri single-cell sequencing platform.
  • Hear about case studies and implementation considerations, including cell and nuclei prep, panel design, and analysis.

Sponsored by

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Tue
Jun
21
1:00 PM
US Eastern

Sponsored by Illumina

DNA Methylation Dynamics and Dysregulation Delineated by High-Throughput Profiling in the Mouse

In this webinar, Peter W. Laird, professor at the Van Andel Research Institute, will discuss the development of a mouse DNA methylation array that contains 296,070 probes representing the diversity of mouse DNA methylation biology. Laird will present a comprehensive validation of this array platform and discuss the applications for comparative epigenomics, genomic imprinting, epigenetic inhibitors, PDX assessment, backcross tracing, and epigenetic clocks. This Infinium Mouse Methylation BeadChip (version MM285) is widely accessible to the research community and will accelerate high sample-throughput studies in this important model organism.

Laird and colleagues have dissected DNA methylation processes associated with differentiation, aging, and tumorigenesis. Notably, the team found that tissue-specific methylation signatures localize to binding sites for transcription factors controlling the corresponding tissue development. Age-associated hypermethylation is enriched at regions of Polycomb repression, while hypomethylation is enhanced at regions bound by cohesin complex members. ApcMin/+ polyp-associated hypermethylation affects enhancers regulating intestinal differentiation, while hypomethylation targets AP-1 binding sites.

Sponsored by

Thu
Jun
23
1:00 PM
US Eastern

Sponsored by Antylia Zeptometrix

Best Practices for Maintaining Quality in Molecular Diagnostic Testing

Molecular diagnostics has quickly become one of the leading global technologies for infectious disease testing. As such, clinicians and physicians rely on the results generated from these tests for accurate patient diagnoses. The field is constantly growing and evolving to meet the demands of infectious disease testing, but what remains constant is the importance for laboratories to maintain rigorous quality management practices, including quality control, to help ensure reliable test results.

With multiple regulatory and accreditation bodies like ISO, CLIA, CAP, and CLSI weighing in on good laboratory and quality practices, it can be challenging to implement a quality management system for your laboratory. This webinar will elucidate the current landscape of considerations for implementing a quality system in laboratories running molecular diagnostic assays, including quality controls.

At the end of this webinar, attendees will be able to:

  1. Describe the relevant regulatory and quality system management principles as they apply to laboratories running molecular diagnostic tests.
  2. Design appropriate quality control strategies for molecular/PCR-based testing methodologies.
  3. Identify tools to help implement effective quality management of molecular diagnostic tests.

Sponsored by

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