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October 15, 2020

A Comparison of cfDNA Approaches to Guide Targeted Therapy in NSCLC

Genome Webinar

Professor of Molecular Oncological Pathology
University Medical Center Groningen

Staff Scientist, Scientific Affairs
Agena Bioscience

In non-small cell lung cancer (NSCLC), early detection of emerging resistance mutations such as EGFR T790M is important in order to determine the appropriate targeted therapeutic strategy.

In this webinar, Prof. Ed Schuuring of University Medical Center Groningen will report on a comparison study for the detection of mutations in plasma DNA of NSCLC patients using the Roche Cobas EGFR v2.0 Mutation Test, BioRad droplet digital PCR, and the Agena Bioscience UltraSEEK Lung Panel. Prof. Schuuring will discuss the detection sensitivity of clinically relevant markers across the platforms and will also highlight the relevance of pre-analytical quality and quantity assessment of cfDNA.

Dr. Alexander Sartori from Agena Bioscience will follow with an overview of the MALDI-TOF based MassARRAY System and available mutation panels for both tissue and plasma DNA in various cancers.