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NTRK fusions are rare but important biomarkers linked to response to new TRK inhibitors. Comprehensive genomic profiling on all solid tumors permits detection of rare genomic events and in the future may enable the use of emerging treatments such as NTRK inhibitors. NTRK genes include numerous potential fusion partners, large intronic regions, and G-C rich content, making accurate and comprehensive detection of NTRK fusions difficult to perform in the lab.