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July 16, 2020

Exploring Tumor Tissue Architecture and Immune Response with Digital Spatial Profiling

Genome Webinar

Assistant Professor of Clinical Dermatology,
University of California, Davis

Holman Research Fellow
Broad Institute

Senior Scientist,
NanoString Technologies

Join this webinar to learn how spatial resolution of gene expression in tumor tissue reveals new insights in biomarker discovery and therapeutic response

Digital spatial profiling of immuno-oncology targets in the tumor, microenvironment, and immune compartments of archival formalin-fixed, paraffin-embedded tissue sections is coupled to downstream next-generation sequencing (NGS) readout. Our speakers will discuss how the NGS readout enables high-throughput and high-plex spatial analysis.

Our first speaker, Margaret Hoang, Senior Scientist, NanoString Technologies will provide a high level overview of the GeoMx Digital Spatial Profiler (DSP), which delivers quantitative high plex, multi-analyte spatial profiling using NGS readout.

Maija Kiuru of the University of California, Davis, will share details of a study that used NanoString’s GeoMx Cancer Transcriptome Atlas to reveal microenvironment-specific expression of a novel cell-type specific biomarker, DAMP, in response to early melanoma development. This marker may allow for more sensitive detection of melanoma via patch biopsy. 

William Hwang of the Broad Institute will then discuss how his team used GeoMx Cancer Transcriptome Atlas and Whole Transcriptome Atlas applications to profile tumor, fibroblast, and immune compartments in pancreatic ductal adenocarcinoma (PDAC) samples from twelve patients. Differential gene expression was measured in tumor and fibroblast compartments between treatment groups and by levels of immune infiltration.