Close Menu
November 13, 2019
Sponsored by
Agena Bioscience

Targeted Detection of MET and NTRK Oncogenic Variants in Routine Molecular Analysis

Genome Webinar

This webinar discusses advances in detecting MET and NTRK variants in tumor samples, which holds significant potential for diagnostic and research applications.  

MET oncogenic variants leading to diverse exon 14 splicing alterations are emerging as a new predictive biomarker that would be sensitizing to MET-targeted tyrosine kinase inhibitors. The splice site DNA somatic variants result in RNA splicing-based skipping of MET exon 14, which supports targeted therapies.

Fusions in the NTRK1, NTRK2 and NTRK3 genes, which encode neurotrophin receptors TRKA, TRKB and TRKC, result in overexpressed kinase function, leading to oncogenesis in a wide variety of adult and pediatric solid tumors. Novel compounds have recently been developed that selectively inhibit TRK fusion proteins. As these alterations affect multiple histologies, detecting the presence of fusions across these genes greatly advances clinical cancer research.

In this webinar, Prof. Hans-Ulrich Schildhaus presents results from a study using a targeted, MALDI-TOF based method for the detection of MET exon 14 alterations and fusions across NTRK1, NTRK2 and NTRK3, and its applicability for routine screening.

Sponsored by
Apr
27
Sponsored by
Biognosys

This webinar, the first in our Next-Generation Proteomics for Precision Oncology series, will discuss how proteomics can help overcome the challenges of treating COVID-19 patients with oncologic comorbidities.

May
26
Sponsored by
Lexogen

The emergence of cell clones that are resistant to targeted therapies poses a significant issue in the treatment of metastatic melanoma.

Jun
16
Sponsored by
Biognosys

This webinar, the second in our Next-Generation Proteomics for Precision Oncology series, will discuss how unbiased discovery proteomics can be used to identify new key mechanisms and signatures supporting clinical decision-making for melanoma patients.

Jun
18
Sponsored by
Canexia Health

Last year, by Precision Oncology News' count, the FDA approved 27 precision oncology drugs, a 35 percent increase in the number of approvals from 2019.