drug resistance
The company is conducting a clinical trial of a pan-variant inhibitor for KIT-mutant GIST and hopes to advance an EGFR pan-variant inhibitor to the clinic soon.
Pfizer, a major player in the space, is exploring two drugs targeting CDK2 to circumvent resistance to CDK4/6 inhibition in HR-positive, HER2-negative breast cancer.
The combinations being studied in a master protocol trial were selected based on research from MSK suggesting the value of blocking KRAS mutations and ERK pathway signaling.
Sequencing-Based MRD Detection in Bone Marrow May Predict ALL Relapse After CAR T-Cell Therapy
Researchers looked at relapse-related markers over time in pediatric and young adult acute lymphoblastic leukemia patients after CAR T-cell treatment.
New Research Consortium to Standardize Single-Cell Sequencing for Cancer Drug Resistance Studies
The main goal of the Persist-Seq private-public consortium is to generate a large single-cell cancer database in order to enable research on drug resistance.