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NEW YORK (GenomeWeb) – Response to anti-PD-1 checkpoint blockade immunotherapy in tumors with mismatch repair (MMR) defects depends on a tumor's overall mutational load and its level of microsatellite instability, as well as the relative proportion of small insertion and deletion (indel) mutations, new research in mouse models and human samples suggests.

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Nov
03

Molecular tumor profiling has provided extensive value, both in tumor biology and oncology, with the development of new technologies to identify biomarkers.

Nov
09
Sponsored by
Akoya Biosciences

Most recent single-cell and spatial biology studies have focused on the network of interactions between different cell types and their spatial context. 

Nov
17

Circular RNAs (circRNAs) have recently gained substantial attention in the cancer research field where most, including the putative oncogene ciRS-7 (CDR1as), have been proposed to function as competitive endogenous RNAs (ceRNAs) by “sponging” specific microRNAs.

Nov
23
Sponsored by
Inivata

In non-small cell lung cancer (NSCLC), liquid biopsy allows detection of driver mutations and can shed light on the development of resistance mutations during treatment.