cancer sequencing
New Mutational Signatures Detected in Cancers Profiled for UK's 100K Genomes Project
Researchers analyzed genome sequences from 18,640 tumors profiled for the 100kGP and other efforts, leading to dozens of substitution signatures and a new signature detection algorithm.
Thermo Fisher Scientific Obtains CE Mark for Ion Torrent Genexus Dx Integrated Sequencer
The company is developing a sample-to-report diagnostic workflow and a portfolio of clinically validated assays for the sequencing platform.
Mass General, Lunaphore Technologies to Develop Test to Predict PARP Inhibitor Response
The collaboration between Mass General and Switzerland's Lunaphore will initially focus on developing a test for ovarian, breast, and prostate cancers.
Cancer Genome Analysis Points to Biallelic Mutations to Inform Variant Interpretation
Investigators saw mutations affecting both maternal and paternal alleles in 21 percent of tumors in a pan-cancer collection, including mutations reflecting a tumor's mutagenic history.
Large-Scale Cancer Genome Analysis Reveals Mutation Clusters That Can Inform Prognosis
With genome sequences for thousands of tumors, researchers identified somatic mutation clusters, mechanisms behind them, and potential ties to patient outcomes.