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gene editing

The Canadian company said its technology platform allows it to match patients to cancer treatments more efficiently and to identify novel patient populations.

The protocol involves using CRISPR-Cas9 gene editing to knock out the NRF2 gene in KRAS-positive NSCLC patients who have become resistant to chemotherapy.

Researchers used a genome-scale CRISPRi platform to identify genetic interactions with an inhibitor for a mutant form of KRAS in models of lung and pancreatic cancer.

Mismatch repair-deficient tumors with many insertion-deletion mutations and enhanced microsatellite instability responded better to anti-PD-1 immunotherapy.

The researchers said their findings could help classify BRCA1 variants, particularly one whose impact on cancer risk is currently not clear.