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New Epigenomic Biomarker Could Predict CAR T-Cell Therapy Resistance in Advanced Childhood Leukemia
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At AACR, researchers described how pediatric ALL patients who don't respond to anti-CD19 CAR T-cell therapy have cancers with a unique, stem cell-like epigenome.
The Israeli firm's ENLIGHT test uses transcriptome sequencing plus functional drug interaction data to match more patients to drugs compared to current methods.
Certain Childhood ALL Subtypes Linked to Genetic Ancestry
With sequence data for thousands of cases in children and young adults, researchers identified tumor molecular subtypes that coincided with patients' genetic ancestry.
Multiomic Profiling Uncovers Predictors of Melanoma Response to Immunotherapy
A model based on the results could predict treatment response but was less able to forecast resistance, suggesting heterogeneous mechanisms.
Researchers Report on Novel Pediatric AML Subtype Associated With Poor Outcomes at ASH Meeting
The analysis suggested that pediatric relapsed AML patients with UBTF tandem duplications had poorer outcomes than those without them.