single-cell analysis
New Epigenomic Biomarker Could Predict CAR T-Cell Therapy Resistance in Advanced Childhood Leukemia
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At AACR, researchers described how pediatric ALL patients who don't respond to anti-CD19 CAR T-cell therapy have cancers with a unique, stem cell-like epigenome.
Molecular Clonal Tracking Method Captures Lung Cancer Treatment Response, Resistance Features
Using a single-cell sequencing and clonal fitness mapping method, researchers compared EGFR-mutant lung cancer cell responses to EGFR inhibition or targeted protein degradation.
Macrophage Subpopulation May Predict Kidney Cancer Recurrence, Serve as Drug Target
The macrophage population, which expressed higher levels of three genes, was enriched in tumors of patients who experienced recurrence after surgery.
Gene Expression Score IDs PD-1/PD-L1 Immune Checkpoint Inhibitor Resistance in Bladder Cancers
Researchers said that the score further may identify patients whose treatment resistance may be overcome with combination strategies targeting certain cells.
Multiple Myeloma Therapy Targets, Resistance Pathways Identified With Single-Cell Sequencing
The researchers found new molecular pathways of resistance, including hypoxia tolerance, protein folding, and mitochondria respiration.